Loxo Oncology - PharmaKB

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Disease Reports

Company ReportsLoxo Oncology

Loxo Oncology(LOXO)

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Therapeutic Areas:

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Include Generics:

Trade Name	Drug Name	Approved	Patent Expires	Indication
Retevmo	Selpercatinib	2020-05-08	2037-2038	Non-small-cell lung carcinoma , Thyroid neoplasms
Jaypirca	Pirtobrutinib	2023-01-27	2036	Mantle-cell lymphoma

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

renal insufficiency

,

hepatic insufficiency

,

,

,

,

breast neoplasms

,

,

non-hodgkin lymphoma

,

,

,

,

,

germ cell and embryonal neoplasms

,

medulloblastoma

,

,

,

,

rhabdomyosarcoma

,

primitive neuroectodermal tumors

,

primitive neuroectodermal tumors peripheral

,

,

,

,

langerhans-cell histiocytosis

,

neuroectodermal tumors

,

colonic neoplasms

,

gastrointestinal neoplasms

,

central nervous system neoplasms

,

nervous system neoplasms

,

histiocytic sarcoma

,

juvenile xanthogranuloma

,

squamous cell carcinoma

,

anaplastic thyroid carcinoma

,

medullary carcinoma

,

papillary carcinoma

,

brain stem neoplasms

,

,

myofibromatosis

,

follicular adenocarcinoma

,

non-small-cell lung carcinoma

,

papillary thyroid cancer

,

,

neuroendocrine carcinoma

,

thyroid neoplasms

,

thyroid diseases

,

pancreatic neoplasms

,

erectile dysfunction

,

,

,

physiological sexual dysfunction

,

blood coagulation disorders

,

hemostatic disorders

,

drug interactions

,

pharmacokinetics

,

,

interstitial lung diseases

,

cardiovascular diseases

,

,

non-alcoholic fatty liver disease

,

,

prostatic neoplasms

,

,

,

respiratory syncytial virus infections

,

,

alzheimer disease

,

systemic scleroderma

,

localized scleroderma

,

diffuse scleroderma

,

,

hepatic insufficiency

,

chronic kidney failure

,

pituitary acth hypersecretion

,

cushing syndrome

,

,

colorectal neoplasms

,

,

non-small-cell lung carcinoma

,

,

therapeutic equivalency

,

transient ischemic attack

,

,

heart valve prosthesis

,

staphylococcus aureus

,

cardiac catheterization

,

,

multi-infarct dementia

,

healthy volunteers/patients

,

intracranial hemorrhages

,

cerebral hemorrhage

,

intracranial thrombosis

,

,

,

replacement arthroplasty knee

,

intracranial sinus thrombosis

,

,

wounds and injuries

,

periodontal diseases

,

subdural hematoma

,

patent foramen ovale

,

secondary prevention

,

neoplasm metastasis

,

,

knee osteoarthritis

,

,

replacement arthroplasty hip

,

traumatic intracranial hemorrhage

,

cerebrovascular disorders

,

hypertensive intracranial hemorrhage

,

subarachnoid hemorrhage

,

cerebral intraventricular hemorrhage

,

cerebral small vessel diseases

,

electric countershock

,

migraine disorders

,

,

,

,

atrial fibrillation

,

thromboembolism

,

venous thromboembolism

,

,

,

,

ischemic stroke

,

venous thrombosis

,

,

,

coronary artery disease

,

coronary disease

,

myocardial ischemia

,

pulmonary embolism

,

cerebral infarction

,

,

acute coronary syndrome

,

myocardial infarction

,

renal insufficiency

,

,

drug-related side effects and adverse reactions

,

heart valve diseases

,

,

cognitive dysfunction

,

atherosclerosis

,

replacement arthroplasty

,

,

chronic renal insufficiency

,

diabetes mellitus

,

,

percutaneous coronary intervention

,

staphylococcal infections

,

,

st elevation myocardial infarction

,

aortic valve disease

,

aortic valve stenosis

,

pathologic constriction

,

mitral valve stenosis

,

kidney diseases

,

ventricular tachycardia

,

ventricular premature complexes

,

intracranial embolism and thrombosis

,

angina pectoris

,

,

non-st elevated myocardial infarction

,

unstable angina

,

embolism and thrombosis

,

,

type 2 diabetes mellitus

,

,

cognition disorders

,

,

,

,

communicable diseases

,

,

postoperative hemorrhage

,

arterial occlusive diseases

,

postoperative complications

,

therapeutic chemoembolization

,

postphlebitic syndrome

,

postthrombotic syndrome

,

hip osteoarthritis

,

,

blood coagulation tests

,

medication adherence

,

vascular diseases

,

,

oral surgical procedures

,

,

uterine hemorrhage

,

antiphospholipid syndrome

,

myeloproliferative disorders

,

craniocerebral trauma

,

,

retinal vein occlusion

,

stomatognathic diseases

,

liver cirrhosis

,

thrombotic stroke

,

hemorrhagic disorders

,

recreational drug use

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

atrial remodeling

,

,

subdural hematoma chronic

,

,

intracranial arteriosclerosis

,

carotid stenosis

,

,

aortic diseases

healthy volunteers/patients

,

head and neck neoplasms

,

precancerous conditions

,

pancreatic neoplasms

,

,

prostatic neoplasms

,

castration-resistant prostatic neoplasms

,

hypersensitivity

,

,

chronic renal insufficiency

,

kidney diseases

,

sickle cell anemia

,

carcinoma in situ

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

renal cell carcinoma

,

human influenza

,

nutritional status

,

pneumococcal infections

,

pneumococcal pneumonia

,

,

,

systemic lupus erythematosus

,

cutaneous lupus erythematosus

,

inflammatory bowel diseases

,

,

,

tendon injuries

,

,

haemophilus influenzae

,

streptococcus pneumoniae

,

,

,

,

energy metabolism

,

endometrial neoplasms

,

,

mullerian mixed tumor

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

non-small-cell lung carcinoma

,

,

neoplasm metastasis

,

,

falciparum malaria

,

ovarian neoplasms

,

brain neoplasms

,

healthy volunteers/patients

,

prostatic neoplasms

,

,

,

colorectal neoplasms

,

squamous cell carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

ovarian epithelial carcinoma

,

cutaneous malignant melanoma

,

,

type 1 diabetes mellitus

,

triple negative breast neoplasms

,

squamous cell carcinoma of head and neck

,

sickle cell anemia

,

myeloid leukemia acute

,

myeloid leukemia

,

,

,

chronic hepatitis b

,

,

primary myelofibrosis

,

hepatocellular carcinoma

,

liver neoplasms

,

fallopian tube neoplasms

,

pancreatic neoplasms

,

,

hematologic neoplasms

,

ductal carcinoma

,

circulating neoplastic cells

,

uterine neoplasms

,

uterine cervical neoplasms

,

,

streptococcus agalactiae

,

,

follicular lymphoma

,

neisseria meningitidis

,

haemophilus influenzae type b

,

invasive hydatidiform mole

,

biliary tract neoplasms

,

uveal neoplasms

,

respiratory tract diseases

,

respiration disorders

,

,

focal segmental glomerulosclerosis

,

cytomegalovirus infections

,

chronic hepatitis

,

kidney diseases

,

membranous glomerulonephritis

,

nephrotic syndrome

,

,

,

endometrioid carcinoma

,

breast diseases

,

squamous cell neoplasms

,

neurofibromatosis 2

,

acoustic neuroma

,

neurofibromatosis 1

,

neurofibromatoses

,

,

,

,

,

pulmonary tuberculosis

,

adenocarcinoma of lung

,

disease progression

,

peritoneal neoplasms

,

,

beta-thalassemia

,

,

sickle cell trait

,

essential thrombocythemia

,

polycythemia vera

,

,

,

,

,

breast neoplasms

,

,

rheumatoid arthritis

,

,

head and neck neoplasms

,

inflammatory breast neoplasms

,

,

respiratory syncytial virus infections

,

,

bacterial infections

,

,

streptococcal infections

,

,

stomach neoplasms

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

infectious skin diseases

,

bacterial skin diseases

,

ductal carcinoma breast

,

renal insufficiency

,

,

,

,

urinary bladder neoplasms

,

acute coronary syndrome

,

,

rotavirus infections

,

,

mucinous adenocarcinoma

,

,

meningococcal meningitis

,

,

respiratory syncytial viruses

,

,

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

acquired immunodeficiency syndrome

,

,

chronic obstructive pulmonary disease

,

communicable diseases

,

,

obstructive lung diseases

,

,

dental focal infection

,

focal infection

,

,

,

immunologic deficiency syndromes

,

ventilator-associated pneumonia

,

growth and development

,

immunologic tests

,

,

alzheimer disease

,

wasting syndrome

,

,

,

insulin resistance

,

abdominal obesity

,

lipid metabolism

,

latent autoimmune diabetes in adults

,

community-acquired infections

,

,

,

staphylococcal infections

,

resistance training

,

,

,

major depressive disorder

,

depressive disorder

,

thyroid neoplasms

,

papillary thyroid cancer

,

thyroid diseases

,

clostridioides difficile

pancreatic neoplasms

,

prostatic neoplasms

,

healthy volunteers/patients

,

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

hematologic neoplasms

,

myeloproliferative disorders

,

myelomonocytic leukemia chronic

,

myeloid leukemia

,

myelomonocytic leukemia juvenile

,

,

,

cholangiocarcinoma

,

healthy volunteers/patients

,

drug interactions

,

,

mitochondrial diseases

,

,

hypersensitivity

,

parkinson disease

,

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

prostatic neoplasms

,

gastrointestinal stromal tumors

,

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

,

rheumatoid arthritis

,

,

sickle cell anemia

,

,

,

,

,

cystic fibrosis

,

,

cardiovascular diseases

,

hypercholesterolemia

,

coronary disease

,

atherosclerosis

,

chronic renal insufficiency

,

kidney diseases

,

type 2 diabetes mellitus

,

diabetes mellitus

,

,

,

diabetes complications

,

,

,

bariatric surgery

,

,

pancreatic neoplasms

,

type 1 diabetes mellitus

,

prediabetic state

,

glucose intolerance

,

exocrine pancreatic insufficiency

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