Loxo Oncology - PharmaKB

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Disease Reports

Company ReportsLoxo Oncology

Loxo Oncology(LOXO)

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Trade Name	Drug Name	Approved	Patent Expires	Indication
Jaypirca	Pirtobrutinib	2023-01-27	2036	Mantle-cell lymphoma

Clinical Trials

Therapeutic Areas:

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Classification:

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Status:

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Phases:

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Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

ischemic stroke

,

,

patent foramen ovale

,

atrial fibrillation

,

thromboembolism

Antithrombin iii

coronary artery disease

,

myocardial ischemia

,

atherosclerosis

,

,

atrial fibrillation

,

sickle cell anemia

,

streptococcus agalactiae

,

,

pulmonary edema

,

,

prostatic neoplasms

,

venous thrombosis

,

human influenza

,

respiratory syncytial virus infections

,

,

,

ovarian neoplasms

,

,

premature obstetric labor

,

,

haemophilus influenzae type b

,

,

,

,

,

,

overactive urinary bladder

,

thrombocytopenic purpura idiopathic

,

thrombocytopenic purpura

,

,

head and neck neoplasms

,

postoperative nausea and vomiting

,

,

,

kidney diseases

,

neisseria meningitidis

,

uterine cervical neoplasms

,

ovarian epithelial carcinoma

,

breast neoplasms

,

gastroenteritis

,

,

chronic obstructive pulmonary disease

,

,

obstructive lung diseases

,

urinary incontinence

,

,

,

postmenopausal osteoporosis

,

knee prosthesis

,

,

stomach neoplasms

,

gastrointestinal neoplasms

,

digestive system neoplasms

,

myocardial infarction

,

,

parkinson disease

,

,

small cell lung carcinoma

,

thrombophlebitis

,

,

,

,

,

urinary tract infections

,

communicable diseases

,

chronic renal insufficiency

,

,

,

,

streptococcal infections

,

,

carcinoma in situ

,

precancerous conditions

,

uterine cervical dysplasia

,

meningococcal infections

,

rotavirus infections

,

post-traumatic stress disorders

,

traumatic stress disorders

,

papillomavirus infections

,

,

fallopian tube neoplasms

,

peritoneal neoplasms

,

,

endometrial neoplasms

,

mucinous adenocarcinoma

,

ductal carcinoma breast

,

inflammatory breast neoplasms

,

acquired immunodeficiency syndrome

,

non-hodgkin lymphoma

,

,

b-cell lymphoma

,

thromboembolism

,

,

venous thromboembolism

,

pulmonary embolism

,

,

acute coronary syndrome

,

renal insufficiency

,

thrombocytopenia

,

,

systemic lupus erythematosus

,

coronary artery bypass

,

critical illness

,

,

cardiovascular diseases

,

,

bacterial infections

,

anxiety disorders

,

depressive disorder

,

chronic obstructive pulmonary disease

,

,

bipolar disorder

,

,

type 2 diabetes mellitus

,

,

,

obstructive lung diseases

,

sleep initiation and maintenance disorders

,

,

non-alcoholic fatty liver disease

,

,

carcinoma in situ

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

,

,

b-cell chronic lymphocytic leukemia

,

b-cell lymphoma marginal zone

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

b-cell lymphoma

,

lymphoid leukemia

ovarian neoplasms

,

,

colonic neoplasms

,

neuroendocrine tumors

,

ovarian epithelial carcinoma

,

endocrine gland neoplasms

,

postoperative nausea and vomiting

,

,

,

chronic renal insufficiency

,

kidney diseases

,

,

chronic hepatitis c

,

,

,

hypercholesterolemia

,

Polyglycolic acid

,

,

stomach neoplasms

,

esophageal neoplasms

,

rectal neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

lymphoid leukemia

,

head and neck neoplasms

,

squamous cell carcinoma

,

squamous cell neoplasms

,

squamous cell carcinoma of head and neck

,

,

sigmoid neoplasms

,

mucinous adenocarcinoma

,

colonic neoplasms

,

cystadenocarcinoma

,

uterine neoplasms

,

endometrial neoplasms

,

ovarian neoplasms

,

ovarian epithelial carcinoma

,

residual neoplasm

,

colorectal neoplasms

,

,

non-small-cell lung carcinoma

,

,

,

neoplasm metastasis

,

,

liver neoplasms

,

myeloid leukemia acute

,

myeloid leukemia

,

pancreatic neoplasms

,

hypercholesterolemia

,

hyperlipoproteinemia type ii

,

breast neoplasms

,

hepatocellular carcinoma

,

gastrointestinal neoplasms

,

neuroendocrine tumors

,

carcinoid tumor

,

paraneoplastic syndromes

,

islet cell adenoma

,

malignant carcinoid syndrome

,

,

venous thrombosis

,

pulmonary embolism

,

,

homozygous familial hypercholesterolemia

,

neurotoxicity syndromes

,

atrial fibrillation

,

thromboembolism

,

myelodysplastic syndromes

,

,

,

laryngeal neoplasms

,

hypopharyngeal neoplasms

,

laryngeal diseases

,

rheumatoid arthritis

,

,

,

glycogen storage disease type ii

,

glycogen storage disease

,

healthy volunteers/patients

,

myelodysplastic syndromes

,

thoracic neoplasms

,

glandular and epithelial neoplasms

,

,

,

pharmacokinetics

,

soft tissue neoplasms

,

digestive system neoplasms

,

,

respiratory tract neoplasms

,

bronchogenic carcinoma

,

endocrine gland neoplasms

,

breast diseases

,

bronchial neoplasms

,

intraductal carcinoma noninfiltrating

,

,

oligodendroglioma

,

,

pancreatic neoplasms

,

neoplasm metastasis

,

,

b-cell lymphoma

,

brain neoplasms

,

large b-cell lymphoma diffuse

,

castration-resistant prostatic neoplasms

,

non-hodgkin lymphoma

,

t-cell lymphoma

,

,

myeloid leukemia acute

,

neuroendocrine tumors

,

cholangiocarcinoma

,

follicular lymphoma

,

neuroendocrine carcinoma

,

t-cell lymphoma peripheral

,

kidney neoplasms

,

thyroid neoplasms

,

pancreatic ductal carcinoma

,

uterine neoplasms

,

uveal neoplasms

,

myeloid leukemia

,

invasive hydatidiform mole

,

lymphoid leukemia

,

,

female genital neoplasms

,

small cell carcinoma

,

urethral neoplasms

,

colonic neoplasms

,

vulvar neoplasms

,

b-cell lymphoma marginal zone

,

,

thyroid diseases

,

cutaneous malignant melanoma

,

,

microsatellite repeats

,

gastrointestinal neoplasms

,

mouth neoplasms

,

oropharyngeal neoplasms

,

laryngeal neoplasms

,

ureteral neoplasms

,

salivary gland neoplasms

,

endometrioid carcinoma

,

serous cystadenocarcinoma

,

mantle-cell lymphoma

,

waldenstrom macroglobulinemia

,

penile neoplasms

,

b-cell chronic lymphocytic leukemia

,

,

,

mullerian mixed tumor

,

,

thymus neoplasms

,

precursor cell lymphoblastic leukemia-lymphoma

,

rectal neoplasms

,

hypopharyngeal neoplasms

,

male genital neoplasms

,

bile duct neoplasms

,

respiratory tract infections

,

papillomavirus infections

,

,

adenoid cystic carcinoma

,

,

male breast neoplasms

,

,

malignant fibrous histiocytoma

,

epstein-barr virus infections

,

adenocarcinoma of lung

,

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

,

,

sezary syndrome

,

mycosis fungoides

,

t-cell lymphoma cutaneous

,

,

pelvic neoplasms

,

hemangiosarcoma

,

,

germ cell and embryonal neoplasms

,

neoplasms by histologic type

,

adenoviridae infections

,

basal cell carcinoma

,

anaplastic thyroid carcinoma

,

reactive arthritis

,

gallbladder neoplasms

,

clear cell adenocarcinoma

,

adenosquamous carcinoma

,

gestational trophoblastic disease

,

alveolar soft part sarcoma

,

biphenotypic leukemia acute

,

local neoplasm recurrence

,

,

,

meningeal carcinomatosis

,

papillomaviridae

,

second primary neoplasms

,

immunoblastic lymphadenopathy

,

enteropathy-associated t-cell lymphoma

,

intestinal diseases

,

,

carcinoma in situ

,

cervical intraepithelial neoplasia

,

uterine cervical dysplasia

,

squamous intraepithelial lesions of the cervix

,

central nervous system diseases

,

extranodal nk-t-cell lymphoma

,

,

,

,

unknown primary neoplasms

,

synovial sarcoma

,

,

oral leukoplakia

,

,

lymphoproliferative disorders

,

,

colonic diseases

,

histiocytic sarcoma

,

follicular dendritic cell sarcoma

,

interdigitating dendritic cell sarcoma

,

environmental biomarkers

,

circulating neoplastic cells

,

inflammatory breast neoplasms

,

meningeal neoplasms

,

intestinal neoplasms

,

central nervous system neoplasms

,

nervous system neoplasms

,

nervous system diseases

,

nerve tissue neoplasms

,

primitive neuroectodermal tumors

,

neuroepithelial neoplasms

,

neuroectodermal tumors

,

adrenocortical carcinoma

,

carcinoid tumor

,

mediastinal neoplasms

,

testicular neoplasms

,

gastrointestinal stromal tumors

,

hairy cell leukemia

,

burkitt lymphoma

,

laryngeal diseases

,

vaginal neoplasms

,

acinar cell carcinoma

,

adenomyoepithelioma

,

hereditary breast and ovarian cancer syndrome

,

maxillary sinus neoplasms

,

basal cell neoplasms

,

urogenital neoplasms

,

male urogenital diseases

,

urogenital diseases

,

,

,

breast neoplasms

,

colorectal neoplasms

,

triple negative breast neoplasms

,

,

renal cell carcinoma

,

ovarian neoplasms

,

,

,

head and neck neoplasms

,

urinary bladder neoplasms

,

prostatic neoplasms

,

stomach neoplasms

,

esophageal neoplasms

,

liver neoplasms

,

hepatocellular carcinoma

,

endometrial neoplasms

,

uterine cervical neoplasms

,

ovarian epithelial carcinoma

,

small cell lung carcinoma

,

transitional cell carcinoma

,

hodgkin disease

,

fallopian tube neoplasms

,

urologic neoplasms

,

multiple myeloma

,

,

squamous cell neoplasms

,

,

plasma cell neoplasms

,

,

esophageal squamous cell carcinoma

,

biliary tract neoplasms

,

malignant mesothelioma

,

peritoneal neoplasms

,

microsatellite instability

,

merkel cell carcinoma

,

non-muscle invasive bladder neoplasms

,

hematologic neoplasms

,

hypersensitivity

,

nasopharyngeal neoplasms

,

nasopharyngeal carcinoma

,

disease progression

,

muscle neoplasms

,

,

non-small-cell lung carcinoma

,

,

squamous cell carcinoma of head and neck

,

squamous cell carcinoma

healthy volunteers/patients

,

,

,

myelodysplastic syndromes

,

myeloid leukemia acute

,

hematologic neoplasms

,

myeloproliferative disorders

,

myelomonocytic leukemia chronic

,

myeloid leukemia

,

myelomonocytic leukemia juvenile

,

,

,

cholangiocarcinoma

,

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